2018 Vol.24 No.2 PP 345-349

TOXICOLOGICAL IMPLICATIONS OF COMBINED CONSUMPTION OF HIGH FAT DIET AND ALCOHOL IN RATS

HEMESHWER KUMAR CHANDRA, GITA MISHRA, NISHA SAHU, SATENDRA KUMAR NIRALA AND ^*MONIKA BHADAURIA

Toxicology and Pharmacology Laboratory,
Department of Zoology, Guru Ghasidas University,
BILASPUR, (C.G.) INDIA
*Corresponding Author : Email : bhadauria_monika@rediffmail.com

ABSTRACT

The aim of the present study was to study the combined toxic effect of high fat diet and alcohol consumption on serological and oxidative stress markers in rats. Rats in control group received regular diet and water for 8 weeks, toxicant group were administered with 30% HFD and 10% alcohol for 2, 4, 6 and 8 weeks respectively.Combined consumption of high fat diet along with alcohol induced hepato-renal toxicity as evident by elevation of serum transaminases, alkaline phosphatase, bilirubin, cholesterol and triglycerides with significant decrease in glucose and albumin. Increased urea and uric acid was also seen in serum. Boosted lipid peroxidation and tissue biochemical parameters and decline in glutathione contents confirmed oxidative stress induced hepatorenal toxicity. Present study showed that 2, 4, 6 and 8 weeks administration of high fat diet along with alcohol significantly disturbed physiological integrity of liver and kidney.

Key words : Genotypes, Green gram, Jassid, Screening, Thrips, Whitefly