2021 Vol.27 No.2 PP 185-190
https://doi.org/10.33451/florafauna.v27i2pp185-190
Momordica charantia constituents and the anti-proliferative activity against an ovarian cancer cell-line SKOV-3
*Vishal Pundir1 and Aditya Chandel2
1Department of Botany,
Tilakdhari Post Graduate College,
JAUNPUR, UTTAR PRADESH - 222002 INDIA
2323 Dr. Martin Luther king Jr Blvd
New Jersey Institute of Technology,
NEWYORK, NJ 07102, U.S.A.
*Corresponding Author :
Email : vpundir341@gmail.com
ABSTRACT
Momordica charantia fruits contain terpenoidal saponins, phenolic acids, minerals and amino acids, all of which are shown to
confer beneficial effects on human health. This study describes a method to conduct qualitative composition analysis of
bioactive compounds in the fresh juice of Momordica charantia fruits harvested locally in Jaunpur (Uttar Pradesh, India)
grown under traditional farming conditions. Fruit juice extract consisting primarily of phenolic acids, showed presence of
12 compounds. Crude extract inhibited the viability of a platinum resistant ovarian cancer cell-line SKOV-3 in-vitro during
48 hours of treatment.
Key words : HPLC, LC–MS, Momordica charantia, Ovarian cancer.