2022 Vol.28 No.1 PP 87-95
https://doi.org/10.33451/florafauna.v28i1pp87-95
Anti cancer potential of 4H- chromene siprooxindole hybrid molecules against Dalton’s Lymphoma (DL) cells
*Shivam Bajpai and Sundaram Singh1
Department of Chemistry,
Bipin Bihari College,
JHANSI- 284001 (U.P.) INDIA.
1Department of Chemistry,
Indian Institute of Technology,
Banaras Hindu University,
VARANASI – 221 005(U.P.) INDIA.
*Corresponding Author :
Email : sbajpai7@gmail.com
ABSTRACT
The anticancer efficacy of 4H- Chromene Spirooxindole hybrid molecules 4i-m1 (Samples 1- 5) was investigated on Dalton’s lymphoma (non-Hodgkin lymphoma) cells. Dalton’s lymphoma (DL) is
a spontaneous and highly invasive T-cell lymphoma that develops as an ascitic tumor in murines. It was observed that treatment of DL cells with compounds showed significant decrease in
cell viability, altered morphology, nuclear disintegration and DNA fragmentation into low molecular weight DNA fragments and thus characteristic of apoptosis. In this view, these compounds
may be used as potential therapeutic regimen to treat this type of cancer in experimental mice.
Key words : Anti-cancer potential, Apoptosis, Dalton’s lymphoma cells, Viability.