2023 Vol. 29 No.2 PP 371-375
https://doi.org/10.33451/florafauna.v29i2pp371-375
Role of NAT-1 gene polymorphism in the etiology and progression of cervical cancer
Balbir Singh, Dwijendra Nath1 and *Ramesh Kumar
Department of Biochemistry,
Bundelkhand University,
JHANSI-284128 ( U.P.) INDIA
1Department of Pathology,
Maharani Laxmibai Medical College,
JHANSI-284128 ( U.P.) INDIA
*Corresponding Author :
E-mail:drramesh.kumar34@gmail.com
ABSTRACT
Cervical cancer (or carcinoma of cervix) incidences show higher occurrence rate in women population residing in poor
socio-economic and unhygienic conditions especially in rural areas. However implication of various effective screening and
health programmes in western countries, the incidence of invasive cervical cancer has declined greatly. In spite of that, still today
cervical cancer remains the most common cancer in women, next to breast and lung cancer, therefore a leading cause of death
in India. Gene polymorphisms modify risk of developing cancer like urinary bladder, colorectal, breast cancer etc. The effect of
NAT-1gene polymorphism on cancer risk varies with organ involved, reflecting tissue specific expression of these genes. Strong
associations exist with cause and increased risk for development of cervical cancer in individuals carrying specific alleles among
the population.
KEY WORDS : Acetylators, Cervical cancer, HPV, Pap (papanicolaou) smear.