2024 Vol. 30 No. 2 PP 187-194

https://doi.org/10.33451/florafauna.v30i2pp187-194

Advanced glycation end products and skin ageing - A Review

Sanjenbam Kabita, Helena Thongam, Langlen Meinam, Laishram Rupachandra Singh and *Sanjenbam Kunjeshwori Dev

Department of Biochemistry,
Manipur University,
CANCHIPUR-795004 (MANIPUR) INDIA
*Corresponding Author
E-mail: kdsanjenbam@yahoo.com

ABSTRACT

Advanced glycation end products (AGEs) are compounds formed by non-enzymatic reaction between the carbonyl group of reducing sugars and amino group of proteins, nucleic acids, and lipids. They are formed in body tissues by both endogenous and exogenous ways. Elevated concentration of AGEs is a prominent feature observed in patients with diabetes mellitus, endstage renal disease, and during ageing. Accumulation of various forms of AGEs are found in both intrinsic and extrinsic types of skin ageing. AGE-modified proteins interact with the receptor for AGE (RAGE) and increase the production of matrix metalloproteinases (MMPs), activate the transcription factor k-B (NFkB) and proinflammatory cytokines, reduce the production of dermal collagen and induce apoptosis of fibroblast via activation of a variety of signalling cascades. This brief review deals with the information on AGEs and the significance of glycation of dermal proteins in skin ageing. It also reviews anti-AGE strategies as a possible approach which may be beneficial in the management of skin ageing

KEY WORDS : Advanced glycation end products (AGEs), Matrix metalloproteinases (MMPs), RAGE, Skin ageing